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Below is a series of principle synthetic reactions that have been
broken down mechanistically with some additional practical notes on
optimising yields. I have also taken a deeper look at some
pharmaceutically relevant heterocyclic materials, namely
functionalised indoles, a moiety which featured heavily in my PhD. | General Aldol Reaction > Knoevenagel Condensation Michael Addition Wittig Reaction > Horner-Wadsworth-Emmons Modification > Schlosser Modification Esterification > Yamaguchi Esterification | Indolisation Fischer Indole Synthesis Madelung Indole Synthesis Larock Indole Synthesis Leimgruber-Batcho Indole Synthesis Bischler-Möhlau Indole Synthesis Bartoli Indole Synthesis | Halogenation Free Radical Halogenation Electrophilic Halogenation (via acid/base) | Cross Coupling Reactions Mizoroki-Heck Reaction Sonogashira Reaction Stille Reaction Suzuki-Miyaura Reaction |
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